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Preclinical and clinical evaluation of topical acid products for skin tumors
Author(s) -
Weiner Murray,
Semah David,
SchewachMillet Miriam,
Cesarini JeanPierre
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.11
Subject(s) - in vivo , fixation (population genetics) , medicine , pathology , dermatology , chemistry , biology , population , microbiology and biotechnology , environmental health
Distinct differences between topical acid preparations can be detected by simple preclinical and clinical pharmacologie models designed to evaluate potential utility in the treatment of superficial skin tumors. The models distinguish a tissue‐dissolving (ulcerating) effect from a tissue‐fixation (mummifying) effect, as reflected by a distinct and lasting discoloration of hair in vitro or the skin surface in vivo. Double‐blind clinical comparison of the response to different preparations of matched pairs of small superficial skin tumors in 33 subjects demonstrated far greater utility for nitric acid preparations of appropriate strength (6 to 7N), with added oxidizable organic acids, over the mineral acid alone. The nitrate reduction products generated in such preparations markedly speed up discoloration in the models and apparently contribute to the improved clinical utility of the topical treatment by enhancing the speed and intensity of tissue fixation, but not tissue erosion. The architecture of lesions eradicated by such mixtures is generally adequately preserved for histologie diagnosis of the extruded tissue. Clinical Pharmacology and Therapeutics (1983) 33, 77–83; doi: 10.1038/clpt.1983.11