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Mezlocillin kinetics in hepatic insufficiency
Author(s) -
Bunke C Martin,
Aronoff George R,
Brier Michael E,
Sloan Rebecca S,
Luft Friedrich C
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.10
Subject(s) - mezlocillin , medicine , hepatic function , prothrombin time , gastroenterology , renal function , endocrinology , biology , genetics , bacteria , pseudomonas aeruginosa , piperacillin
To establish elimination kinetics of mezlocillin in patients with hepatic insufficiency, we gave eight normal subjects and four patients with hepatic insufficiency and normal renal function a single 3‐gm dose of mezlocillin by intravenous infusion. Subjects with hepatic insufficiency all had serum bilirubins levels of above 3 mg/dl, Prothrombin times more than 2 sec longer than control, and Creatinine clearances above 60 ml/min. Mezlocillin concentrations were determined by microbiologie assay. Kinetic analysis was by model‐independent methods. Elimination half‐life was 0.96 hr for subjects with normal liver function and 2.62 hr for patients with hepatic insufficiency. Mean total body clearance for normal subjects was 247 ml/min, while in patients with hepatic insufficiency it was 125.4 ml/min. We conclude that hepatic insufficiency prolongs mezlocillin elimination and suggest that therapeutic guidelines be set up. Clinical Pharmacology and Therapeutics (1983) 33, 73–76; doi: 10.1038/clpt.1983.10