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Antihypertensive and renal effects of captopril in relation to renin activity and bradykinin‐induced vasodilation
Author(s) -
Kiowski Wolfgang,
Brummelen Peter,
Hulthen Lennart,
Amann Franz W,
Bühler Fritz R
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.95
Subject(s) - captopril , plasma renin activity , bradykinin , blood pressure , medicine , renin–angiotensin system , vasodilation , angiotensin converting enzyme , essential hypertension , hemodynamics , brachial artery , endocrinology , cardiology , pharmacology , receptor
The effect of captopril on blood pressure and renal hemodynamics in relation to plasma renin activity (PRA) was assessed together with the vasodilator responses to brachial artery infusions of bradykinin (BK) and sodium nitroprusside (NP) before and after 4 wk of therapy with doses of up to 450 mglday in patients with essential hypertension. The average blood pressure reduction of captopril was from 174.4/110.6 to 155.3/96.6 mm Hg (n = 12, P < 0.001) without increases in heart rate or body weight. It was effective in the eight patients with normal renin, but showed little effect in the four with a low renin. There was a correlation between the changes in blood pressure after captopril and the pretreatment PRA (r = −0.82, P < 0.01 for mean pressure). Brachial artery infusions of BK and NP induced dose‐dependent rises in forearm blood flow (FBF), but this was not related to the captopril blood pressure‐lowering effect. Repeat measurements during captopril therapy showed a shift to the left of the BK/FBF, but not of the NP/FBF, dose‐response curve, indicating effective vascular kininase II inhibition. Captopril decreased renal vascular resistance. Our data are compatible with the view that captopril's antihypertensive action mainly involves blockade of the renin‐angiotensin‐aldosterone system and not cumulation of BK. The favorable effects on renal hemodynamics and the lack of tachycardia and volume retention after captopril make it a valuable drug for the treatment of hypertension. Clinical Pharmacology and Therapeutics (1982) 31 , 677–684; doi: 10.1038/clpt.1982.95