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Age and renal clearance of cimetidine
Author(s) -
Drayer Dennis E,
Romankiewicz John,
Lorenzo Beverly,
Reidenberg Marcus M
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.7
Subject(s) - cimetidine , clearance , creatinine , medicine , renal function , urine , endocrinology , pharmacology , urology
In 35 patients (ages 20 to 86 yr) receiving cimetidine therapeutically two serum samples and all urine formed in the interim were collected for analysis of cimetidine by high‐pressure liquid chromatography and for creatinine. Cimetidine clearance decreased with age. The extrapolated 6‐hr serum concentration of cimetidine per unit dose, after intravenous cimetidine, increased with age of the patients. The ratio of cimetidine clearance to creatinine clearance (Rc) averaged 4.8 ± 2.0, indicating net tubular secretion for cimetidine. Rc seemed to be independent of age and decreased with increasing serum concentration of cimetidine, suggesting that secretion of cimetidine is a saturable process. There was only one case of dementia possibly due to cimetidine (with a drug level of 1.9μg/ml 6 hr after a dose) in a group of 13 patients without liver or kidney disease who had cimetidine levels above 1.25 μg/ml. Thus, high cimetidine levels alone do not always induce dementia. Clinical Pharmacology and Therapeutics (1982) 31 , 45–50; doi: 10.1038/clpt.1982.7