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Ceftizoxime kinetics and renal handling
Author(s) -
Dubb Jeffrey,
Actor Paul,
Pitkin Donald,
Alexander Fred,
Familiar Robert,
Ehrlich Stephen,
Stote Robert
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.69
Subject(s) - probenecid , ceftizoxime , chemistry , pharmacology , renal physiology , renal function , medicine , biochemistry , cefotaxime , antibiotics
The kinetics and renal handling of ceftizoxime were examined after intravenous and intramuscular injection and the effect of probenecid on its excretion was investigated. Peak serum level after 1000 mg IV was 60.5 μg/ml and half‐life (t½) was 1.4 hr. Peak serum level (40.9 μg/ml) was reached 1 hr after 1000 mg IM. When probenecid was added to the 1000‐mg IM dose the peak level was 44.3 μg/ml at 1 hr and serum levels at 2, 4, 6, and 8 hr were all higher than after ceftizoxime alone (P < 0.01). The 1.85‐hr t½ of ceftizoxime alone was extended to 2.29 hr when probenecid was added. Ceftizoxime was shown to be actively secreted by the renal tubule; this secretion was decreased by probenecid. Clinical Pharmacology and Therapeutics (1982) 31, 516–521; doi: 10.1038/clpt.1982.69