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Free and bound choline blood levels after phosphatidylcholine
Author(s) -
Jope Richard S,
Domino Edward F,
Mathews Benjamin N,
Sitaram Natraj,
Jenden Donald J,
Ortez Aurelio
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.64
Subject(s) - choline , phosphatidylcholine , chemistry , lecithin , medicine , endocrinology , blood plasma , biochemistry , phospholipid , membrane
In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline‐containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline‐containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired. Clinical Pharmacology and Therapeutics (1982) 31, 483–487; doi: 10.1038/clpt.1982.64