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Aspirin blocks nicotinic acid–induced flushing
Author(s) -
Wilkin Jonathan K,
Wilkin Olive,
Kapp Ronald,
Donachie Robert,
Chernosky Marvin E,
Buckner Joyce
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.63
Subject(s) - aspirin , flushing , nicotinic agonist , pharmacology , chemistry , medicine , biochemistry , endocrinology , receptor
Nicotinic acid flushing after placebo and 975‐mg oral doses of aspirin was assessed in 29 normal subjects over a range of nicotinic acid doses. Intensity of flushing was assessed by the change in malar thermal circulation index (ΔMTCI). Aspirin pretreatment resulted in smaller ΔMTCIs at the higher doses of nicotinic acid. At the lower doses the change in the index after pretreatments with both aspirin and placebo remained low, suggesting that very little flushing was provoked by these doses. These results are compatible with the proposed mediation by prostaglandins of the nicotinic acid–induced flush. According to the ΔMTCI method, flushing is quantitatively characterized as a nonquantal, dose‐response reaction of variable intensity. Clinical Pharmacology and Therapeutics (1982) 31, 478–482; doi: 10.1038/clpt.1982.63