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Hemodynamic effects of diuretics in patients with marked peripheral edema and mild hypertension
Author(s) -
Niarchos Andreas P,
Magrini Fabio
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.47
Subject(s) - furosemide , peripheral edema , spironolactone , diuretic , medicine , edema , chlorthalidone , hemodynamics , blood pressure , cardiac output , anesthesia , cardiology , heart failure , adverse effect
Hypertension develops in about 10% to 50% of patients with nephrosis or cirrhosis and peripheral edema, but the hemodynamic mechanism of the hypertension and its reversal by diuretic therapy has not been elucidated. In eight patients with marked edema and mild hypertension, diuretics (furosemide and spironolactone) decreased mean arterial pressure because of concurrent decrease in cardiac output and total peripheral resistance. Neither total blood volume nor plasma volume were decreased by the diuretics and the decrease in body weight was therefore attributed to the decrease in interstitial fluid volume. This, in turn, resulted in increased venous capacitance (as can be judged from the diuretic‐induced decrease in the ratio of cardiopulmonary blood volume/total blood volume). Clinical Pharmacology and Therapeutics (1982) 31, 370–376; doi: 10.1038/clpt.1982.47