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Peripheral arterial and venous responses to acetylstrophanthidin in patients with acute myocardial infarction
Author(s) -
Creager Mark A,
Halperin Jonathan L,
Klein Michael D,
Coffman Jay D
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.230
Subject(s) - medicine , cardiology , digitalis , myocardial infarction , heart failure , pulmonary wedge pressure , central venous pressure , blood pressure , vascular resistance , cardiac output , anesthesia , venous return curve , hemodynamics , heart rate
The peripheral arterial and venous responses to rapidly active acetylstrophanthidin (rather than the much slower digitalis) were studied in patients with acute myocardial infarction without congestive heart failure. In eight control patients placebo did not change mean blood pressure (BP), calf blood flow (CBF), calf vascular resistance (CVR), or calf venous volume (CVV). Seventeen patients received 10 mg IV acetylstrophanthidin. In these patients BP increased 5.3%, CBF decreased 18.2%, and CVR increased 29.2%. Venous capacitance was not changed. Acetylstrophanthidin induced no significant change in cardiac output, systemic vascular, resistance, pulmonary capillary wedge pressure, or right atrial pressure. In patients with acute myocardial infarction not complicated by congestive heart failure, digitalis may promote limb vasoconstriction and increase blood pressure, but it does not adversely affect cardiac function. Clinical Pharmacology and Therapeutics (1982) 32 , 736–743; doi: 10.1038/clpt.1982.230