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Lack of effect of diazepam on methadone metabolism in methadone‐maintained addicts
Author(s) -
Pond Susan M,
Tong Theodore G,
Benowitz Neal L,
Jacob Peyton,
Rigod Jean
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.22
Subject(s) - methadone , diazepam , pharmacology , metabolite , addiction , clinical pharmacology , pharmacokinetics , medicine , metabolism , drug , drug metabolism , chemistry , psychiatry
Four methadone‐maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man. Clinical Pharmacology and Therapeutics (1982) 31 , 139–143; doi: 10.1038/clpt.1982.22