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Nortriptyline formation after single oral and intramuscular doses of amitriptyline
Author(s) -
Mellström B,
Alván G,
Bertilsson L,
Potter W Z,
Säwe J,
Sjöqvist F
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.219
Subject(s) - nortriptyline , amitriptyline , dosing , pharmacology , plasma concentration , oral administration , intramuscular injection , clinical pharmacology , plasma levels , pharmacokinetics , medicine , oral dose , anesthesia , chemistry
Oral (50 mg) and intramuscular (25 mg) amitriptyline (AT) was given to six normal subjects and the area under the plasma concentration‐time curve (AUC) for nortriptyline (NT) formed was calculated. There was no difference between the AUCs (corrected for dose) after the two routes of administration. The ratio between AUC oral and AUC im averaged 0.95 (range 0.69 to 1.13). After intramuscular AT maximum NT plasma concentration was reached after 24 to 48 hr, whereas it was 8 to 24 hr after oral dosing. Clinical Pharmacology and Therapeutics (1982) 32, 664–667; doi: 10.1038/clpt.1982.219