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Effects of cancer and its treatments on plasma concentration of alpha 1 ‐acid glycoprotein and propranolol binding
Author(s) -
Abramson Fred P,
Jenkins Jean,
Ostchega Yechiam
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.218
Subject(s) - propranolol , orosomucoid , albumin , free fraction , endocrinology , medicine , chemistry , blood proteins , glycoprotein , cancer , plasma concentration , serum albumin , plasma protein binding , pharmacology , biochemistry
The plasma concentrations of α 1 acid glycoprotein (AAG) and albumin, and the plasma protein binding of propranolol were measured in a group of cancer patients and a group of normal subjects. In cancer patients the AAG concentrations were twice that in controls (142 and 78 mg/dl, P < 0.005), the albumin concentrations were lower (3.11 and 4.37 gm/dl, P < 0.001), and the free fraction of propranolol was lower (0.127 and 0.190, P < 0.005). Propranolol binding correlated strongly with AAG concentrations. These data imply that untreated or unsuccessfully treated cancer patients will have reduced free fractions for any drug for which AAG is an important binding protein. Successfully treated patients may have longitudinal changes towards normal. No consistent effect of the treatments themselves on AAG was observed after radiation therapy in five patients or after intravenous adriamycin in six patients. Clinical Pharmacology and Therapeutics (1982) 32, 659–663; doi: 10.1038/clpt.1982.218