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Urine pH and phencyclidine excretion
Author(s) -
PerezReyes Mario,
Guiseppi Stephanie Di,
Brine Dolores R,
Smith Helen,
Cook C Edgar
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.214
Subject(s) - urine , perspiration , chemistry , phencyclidine , diuresis , excretion , sodium bicarbonate , pharmacology , medicine , renal function , biochemistry , nmda receptor , receptor , psychiatry
Subeffective doses (0.5 mg) of 3 H‐phencyclidine (PCP) were given intravenously to three healthy men under two regimens designed to alkalinize or acidify their urine (oral sodium bicarbonate or ammonium chloride). The concentrations of PCP and its metabolites in saliva, plasma, and urine for 7 hr after drug injection were determined by high‐performance liquid radiochromatography. A sample of perspiration from one subject was analyzed. The effects of physical exercise on the plasma concentration and urinary excretion of PCP were also studied. Multiple linear regression analysis showed the logarithm of renal clearance to be dependent on urine pH (P < 0.0001), the logarithm of urine volume per unit time (P = 0.003), and the individual subject (P =0.016). Exercise decreased urine pH and increased the renal clearance of PCP. PCP and its metabolites are also excreted in perspiration. Our results support clinical reports of the importance of vigorous acidification of urine and diuresis in treatment of PCP intoxication. Clinical Pharmacology and Therapeutics (1982) 32, 635–641; doi: 10.1038/clpt.1982.214