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Absorption of controlled‐release iron
Author(s) -
Cook James D,
Lipschitz David A,
Skikne Barry S
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.198
Subject(s) - elixir (programming language) , capsule , absorption (acoustics) , chemistry , ferrous , meal , ferrous sulphate , pharmacology , medicine , food science , materials science , inorganic chemistry , organic chemistry , biology , botany , computer science , composite material , programming language
A multiple‐dose double radioiron technic was used to compare absorption of iron administered as a controlled‐release (CR) capsule and as an elixir; both formulations contained 50 mg elemental iron as ferrous sulfate. When taken by normal subjects in the fasting state, mean absorption from the elixir and CR capsule averaged 4.92% and 4.38%, which gave a CR capsule: elixir ratio of 0.89. This difference was not significant, but when taken with meals that inhibit absorption of dietary iron by different degrees, absorption of the CR formulation was superior. CR capsule: elixir absorption ratios averaged 1.70 from a meal that is mildly inhibitory and 3.13 from a meal that causes more marked inhibition. It is concluded that CR iron formulations may offer a therapeutic advantage to patients who take oral iron with meals to avoid gastrointestinal side effects. Clinical Pharmacology and Therapeutics (1982) 32 , 531–539; doi: 10.1038/clpt.1982.198