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Analysis of the pressor dose response
Author(s) -
J Sumner David,
Elliott Henry L,
Reid John L
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.188
Subject(s) - prazosin , phenylephrine , schild regression , pressor response , antagonist , doxazosin , atenolol , mathematics , sigmoid function , dose–response relationship , medicine , anesthesia , pharmacology , blood pressure , heart rate , computer science , receptor , machine learning , artificial neural network
(1) When incremental infusions of drugs that increase blood pressure are given to human subjects to assess “pressor responsiveness,” only the lower part of the sigmoid dose‐response curve can be obtained. (2) Fitting a quadratic function does not involve discarding data points, which is usually the case with a linear fit, and it provides a more satisfactory fit to the lower part of a sigmoid dose‐response curve. (3) In the presence of a competitive antagonist, a pressor dose‐response curve will be shifted to the right. In this situation the dose‐response curves obtained before and after treatment with antagonist should be fitted simultaneously to a quadratic model in which the parallel shift is one of the parameters. (4) The use of quadratic fitting is illustrated by reference to clinical experiments to obtain the following three curves for drugs that modify peripheral alpha adrenoceptors: norepinephrine pressor response curves after placebo and doxazosin, an alpha 1 antagonist; norepinephrine pressor response curves after placebo, labetalol, and medroxalol (drugs with combined alpha 1 and beta blocking properties); and phenylephrine pressor response curves before and after prazosin. (5) Fitting a quadratic function is the appropriate initial step in the analysis of pressor dose‐response curves in man. Clinical Pharmacology and Therapeutics (1982) 32 , 450–458; doi: 10.1038/clpt.1982.188