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Kinetics of the digoxin‐aspirin combination
Author(s) -
Fenster Paul E,
Comess Keith A,
Hanson Christine Dahl,
Finley Paul R
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.184
Subject(s) - digoxin , aspirin , pharmacology , creatinine , medicine , volume of distribution , dosing , chemistry , pharmacokinetics , heart failure
Digoxin interacts kinetically with many drugs in man. These interactions may result in digoxin toxicity. Aspirin has been shown to raise serum digoxin levels in the dog. We evaluated the effect of aspirin on digoxin single‐dose kinetics in eight healthy adults. Aspirin induced no change in digoxin total body clearance, volume of distribution, elimination half‐life, or renal or creatinine clearance. Trough serum salicylate levels ranged from 93 to 163 μg/ml. We conclude that no alteration is required in digoxin dosing when aspirin is used. Clinical Pharmacology and Therapeutics (1982) 32 , 428–430; doi: 10.1038/clpt.1982.184