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Tolmetin kinetics and synovial fluid prostaglandin E levels in rheumatoid arthritis
Author(s) -
Dromgoole Sydney H,
Furst Daniel E,
Desiraju Ravi K,
Nayak Ramchandra K,
Kirschenbaum Michael A,
Paulus Harold E
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.174
Subject(s) - synovial fluid , rheumatoid arthritis , prostaglandin , chemistry , medicine , endocrinology , plasma concentration , pharmacology , pathology , osteoarthritis , alternative medicine
Tolmetin kinetics were determined in the plasma and synovial fluid of five rheumatoid arthritis patients after they had ingested tolmetin (400 mg every 6 hr) for 7 days. Tolmetin was rapidly absorbed, with average peak levels in plasma and synovial fluid occurring at 45 min and 2 hr. The drug concentration in synovial fluid was higher than that in plasma for prolonged periods, while the rates of elimination from both plasma and synovial fluid were similar. The average half‐lifes of tolmetin in plasma and synovial fluid were 6.77 ± 1.47 hr and 6.90 ±2.3 hr. Total prostaglandin E levels in synovial fluid of these patients were suppressed for at least 24 hr after the last dose of tolmetin, suggesting that PGE synthesis continues to be suppressed even by the very low concentrations of tolmetin remaining after 24 hr. Clinical Pharmacology and Therapeutics (1982) 32, 371–377; doi: 10.1038/clpt.1982.174