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Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals
Author(s) -
Døssing Martin
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.169
Subject(s) - pesticide , chemistry , microsome , toxicology , discontinuation , occupational exposure , toxicity , pharmacology , physiology , enzyme , medicine , biochemistry , biology , emergency medicine , organic chemistry , agronomy
Antipyrine clearance was measured during occupational exposure and after an exposure‐free interval of 3 wk in 26 spray painters, 44 workers in a herbicide‐producing (phenoxyacids) plant, and 10 pesticide‐exposed greenhouse gardeners. A control group of 39 workers were investigated simultaneously. A noninvasive simplified antipyrine clearance was used. Antipyrine clearance was greater by 15% in workers exposed to phenoxyacids and chlorophenols and 21% greater in pesticide‐exposed persons, but it was 15% less in workers exposed to spray paints compared to 3 wk after discontinuation of exposure. Clearance was unchanged in the control group examined at the same interval. Thus, the combined action of different spray paints, grinding dust, and cleaners may inhibit, and phenoxyacids, chlorophenols, and various pesticides may induce, the microsomal enzyme function. The workers had been exposed to the chemicals for years, but the change in antipyrine clearance apparently was reversible. Clinical Pharmacology and Therapeutics (1982) 32, 340–346; doi: 10.1038/clpt.1982.169