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Hydralazine and furosemide kinetics
Author(s) -
Nomura Akikazu,
Yasuda Hisakazu,
Katoh Kunihiko,
Akimoto Tsugio,
Miyazaki Katsumi,
Arita Takaichi
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.164
Subject(s) - furosemide , hydralazine , renal function , medicine , heart failure , metabolic clearance rate , clinical pharmacology , chemistry , kinetics , clearance , pharmacokinetics , pharmacology , endocrinology , urology , physics , quantum mechanics , blood pressure
Furosemide kinetics were studied in 25 patients with congestive heart failure. The elimination half‐life (t½) was longer and the elimination rate constant and the plasma clearance smaller in patients with advanced (n = 15) than in those with moderate (n = 10) failure. Furosemide kinetics with and without hydralazine were compared in eight patients with advanced heart failure. Furosemide t½ in patients receiving both drugs fell from 96 ± 16 to 81 ± 15 min (P < 0.02), elimination rate constant increased from 0.0186 ± 0.0056 to 0.0214 ± 0.0068 min −1 (P < 0.05), and plasma clearance rose from 72.6 ± 18.5 to 88.1 ± 26.9 ml/min (P < 0.01). Renal clearance rose from 45.4 ± 12.0 to 60.9 ± 19.0 ml/min (P < 0.01) and creatinine clearance was unchanged. We conclude that hydralazine affects furosemide kinetics. Clinical Pharmacology and Therapeutics (1982) 32, 303–306; doi: 10.1038/clpt.1982.164