Hydralazine and furosemide kinetics | Zendy

Nomura Akikazu | Zendy; Yasuda Hisakazu | Zendy; Katoh Kunihiko | Zendy; Akimoto Tsugio | Zendy; Miyazaki Katsumi | Zendy; Arita Takaichi | Zendy

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Hydralazine and furosemide kinetics

Author(s) -

Nomura Akikazu,

Yasuda Hisakazu,

Katoh Kunihiko,

Akimoto Tsugio,

Miyazaki Katsumi,

Arita Takaichi

Publication year - 1982

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.1982.164

Subject(s) - furosemide , hydralazine , renal function , medicine , heart failure , metabolic clearance rate , clinical pharmacology , chemistry , kinetics , clearance , pharmacokinetics , pharmacology , endocrinology , urology , physics , quantum mechanics , blood pressure

Furosemide kinetics were studied in 25 patients with congestive heart failure. The elimination half‐life (t½) was longer and the elimination rate constant and the plasma clearance smaller in patients with advanced (n = 15) than in those with moderate (n = 10) failure. Furosemide kinetics with and without hydralazine were compared in eight patients with advanced heart failure. Furosemide t½ in patients receiving both drugs fell from 96 ± 16 to 81 ± 15 min (P < 0.02), elimination rate constant increased from 0.0186 ± 0.0056 to 0.0214 ± 0.0068 min −1 (P < 0.05), and plasma clearance rose from 72.6 ± 18.5 to 88.1 ± 26.9 ml/min (P < 0.01). Renal clearance rose from 45.4 ± 12.0 to 60.9 ± 19.0 ml/min (P < 0.01) and creatinine clearance was unchanged. We conclude that hydralazine affects furosemide kinetics. Clinical Pharmacology and Therapeutics (1982) 32, 303–306; doi: 10.1038/clpt.1982.164

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