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Kinetics of osmotically controlled indomethacin delivery systems after repeated dosing
Author(s) -
Bayne W,
Place V,
Theeuwes F,
Rogers J D,
Lee R B,
Davies R O,
Kwan K C
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.158
Subject(s) - dosing , clinical pharmacology , morning , pharmacology , plasma concentration , crossover study , medicine , pharmacokinetics , capsule , urinary system , chemistry , biology , botany , alternative medicine , pathology , placebo
Two osmotically driven, controlled‐release dosage forms of indomethacin were evaluated in a multiple‐dose crossover study in 12 healthy subjects. Following equivalent daily doses, less frequent dosing of both controlled‐release forms resulted in plasma concentration profiles that are more uniform than those following capsule regimens. After the first day, morning predose plasma levels were significantly higher for the controlled‐release treatments. Renal clearances were similar between days and among treatments. Total urinary recoveries were comparable for all regimens. Clinical Pharmacology and Therapeutics (1982) 32, 270–276; doi: 10.1038/clpt.1982.158