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Piroxicam, aspirin, and gastrointestinal blood loss
Author(s) -
Bianchine Joseph R,
Procter Robert R,
Thomas Fred B
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.155
Subject(s) - piroxicam , aspirin , medicine , clinical pharmacology , irritation , anesthesia , blood loss , gastroenterology , pharmacology , surgery , pathology , alternative medicine , immunology
A study to compare the effects of three piroxicam regimens and aspirin on fecal blood loss (FBL) was conducted among 39 healthy men. Fourteen of the subjects also underwent prestudy and poststudy gastroscopy. There was an increase in FBL after aspirin, 972 mg 4 times a day, whereas piroxicam, 20 mg once a day, 5 mg four times a day, and 10 mg four times a day induced no observable increase in fecal blood loss. There was gastroscopic evidence of irritation in the aspirin group, but not in any of the piroxicam groups. Clinical Pharmacology and Therapeutics (1982) 32, 247–252; doi: 10.1038/clpt.1982.155