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Lymphocyte β‐adrenergic receptors are not altered in hyperthyroidism
Author(s) -
Hui Ka Kit P,
Wolfe Robert N,
Conolly Matthew E
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.142
Subject(s) - euthyroid , dihydroalprenolol , endocrinology , triiodothyronine , medicine , receptor , adrenergic receptor , lymphocyte , adrenergic , hormone , chemistry , agonist , partial agonist
Binding of (‐)[ 3 H]‐dihydroalprenolol ( 3 H‐DHA) to lymphocytes from five thyrotoxic patients and five age‐ and sex‐matched controls were examined to ascertain whether β‐adrenergic receptor number or binding affinity were altered in thyrotoxicosis. Whereas an increase in β‐adrenoceptor density has been reported in triiodothyronine‐induced hyperthyroidism, we did not find changes in β‐adrenergic receptor density or binding affinity. In one patient studied sequentially, we did not find alteration in 3 H‐DHA binding before or after the subject was rendered euthyroid. We conclude that lymphocyte β‐adrenergic receptor density and affinity are not altered in spontaneous hyperthyroidism. Clinical Pharmacology and Therapeutics (1982) 32, 161–165; doi: 10.1038/clpt.1982.142