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Effects of cardioselective and nonselective beta‐adrenergic antagonists on pulmonary mechanics
Author(s) -
Foley James E,
Sigurdson Maureen J,
Conliffe Therese F,
Fand Rita S,
Anthonisen Nicholas R
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.140
Subject(s) - nadolol , medicine , metoprolol , propranolol , anesthesia , vital capacity , placebo , airway resistance , functional residual capacity , cardiology , lung volumes , airway , lung , lung function , diffusing capacity , alternative medicine , pathology
After a 7‐day placebo lead‐in period, one of three β‐adrenergic antagonists was taken for 2 wk by 10 healthy male subjects. The drugs were metoprolol (cardioselective) and propranolol and nadolol (both nonselective). Dosage was according to currently recommended regimens and was increased after the first week (50 to 100 mg b.i.d., 20 to 40 mg q.i.d., and 80 to 160 mg q.d.). Pulmonary mechanics and density dependence (DD) of maximal expiratory flow were measured before and at the end of the placebo lead‐in period and the low‐ and high‐dose treatment weeks. Total lung capacity (TLC), residual volume (RV), and RV/TLC all rose (P < 0.05) after high‐dose nadolol. Forced vital capacity (FVC) and expiratory reserve volume fell (P < 0.05) after high‐dose metoprolol. There was no change in forced expiratory volume in 1.0 sec (FEV 1 ), FEV 1 /FVC, maximal midexpiratory flow rate, or airway resistance with any of the β‐antagonists. Decreases (P < 0.05) in maximal expiratory flow determined at 50% of the vital capacity occurred after propranolol and metoprolol, but not after nadolol. A dose‐related decrease in DD at 50% of the vital capacity accompanied nadolol dosing, but was significant only after the high‐dose regimen. The decreases in DD with nadolol, as well as its effect on RV/TLC, are consistent with small airway narrowing. The findings with metoprolol and propranolol suggest that they affect central as well as peripheral airways. Clinical Pharmacology and Therapeutics (1982) 32, 149–155; doi: 10.1038/clpt.1982.140