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Kinetics of drug effect by distributed lags analysis: An application to cocaine
Author(s) -
Zahler Raphael,
Wachtel Paul,
Jatlow Peter,
Byck Robert
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.110
Subject(s) - drug , kinetics , dissociation (chemistry) , plasma concentration , chemistry , pharmacology , econometrics , computer science , statistical physics , medicine , mathematics , physics , classical mechanics
The same plasma drug concentration may induce different effects depending on whether the concentration is rising or falling. We describe a new method of modeling kinetics of drug effects that can handle such “dissociation” phenomena, that does not depend on compartmental theory, and that allows quantitative comparisons between experiments. As applied to cocaine, it is shown that the resulting models are independent of drug dose or route of administration and give good predictions of the time course of response. Clinical Pharmacology and Therapeutics (1982) 31 , 775–782; doi: 10.1038/clpt.1982.110