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Coffee and caffeine and alcohol effects on psychomotor function
Author(s) -
Nuotto E,
Mattila M J,
Seppälä T,
Konno K
Publication year - 1982
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1982.11
Subject(s) - caffeine , alcohol , psychomotor learning , placebo , crossover study , ethanol , blood alcohol , pharmacology , anesthesia , medicine , psychology , chemistry , poison control , injury prevention , biochemistry , cognition , psychiatry , medical emergency , alternative medicine , pathology
Interactions of alcohol and caffeine were studied in two double‐blind and crossover trials in which several psychophysiologic functions and subjective effects were measured in healthy men. The effects of alcohol (1 gm/kg) with and without caffeine (200 or 500 mg) were measured in 10 subjects. Two doses (0.7 or 7.5 gm/kg) of alcohol alone and in combination with caffeine (250 + 250 mg) were similarly studied in another 10 subjects. Alcohol impaired psychomotor functions to an extent dependent on dose whereas caffeinated and decaffeinated coffee did not. Both kinds of coffee also failed to modify alcohol effects. Subjectively, caffeine was indistinguishable from placebo and no particular interaction of alcohol and caffeine was detected. Alcohol did elevate serum caffeine concentrations. We conclude that coffee does not counteract alcohol inebriation. Clinical Pharmacology and Therapeutics (1982) 31 , 68–76; doi: 10.1038/clpt.1982.11