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A comparison of methods of lidocaine administration in patients
Author(s) -
Salzer Lisa B,
Weinrib Arnold B,
Marina Richard J,
Lima John J
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.86
Subject(s) - lidocaine , clinical pharmacology , medicine , plasma concentration , pharmacology , anesthesia , plasma levels
A three‐step method for administering lidocaine intravenously was developed and tested in 19 patients. Of all plasma concentrations measured, 70% were within the desired range of 2 to 4 µg/ml after the new method of lidocaine administration. Compared with other methods it is superior with respect to percent of time in the therapeutic range. No ventricular arrhythmias were evident, and no toxicities were associated with the new method. Infusions of lidocaine for more than 6 hr were associated with progressive increases in plasma concentrations that were higher (p < 0.01) at 24 hr than at 6 hr. Clinical Pharmacology and Therapeutics (1981) 29, 617–624; doi: 10.1038/clpt.1981.86