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The method of separate exponentials: A simple aid to devising intravenous drug‐loading regimens
Author(s) -
Shand D G,
Desjardins R E,
Bjornsson T D,
Hammill S C,
Pritchett E L C
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.76
Subject(s) - regimen , simple (philosophy) , pharmacology , exponential function , medicine , drug , intravenous drug , phase (matter) , computer science , mathematics , chemistry , immunology , mathematical analysis , philosophy , epistemology , virus , organic chemistry , viral disease
Simulation of complex dosage regimens for drugs with multicompartmental kinetics is described using the method of separate exponentials. This approach requires that α‐ and β‐phases are treated separately throughout and summed only at the end of the simulation. The method was used to devise a loading regimen for pirmenol, comprising a priming injection, and a rapid loading infusion, followed by a maintenance infusion. The regimen was tested in a patient with excellent agreement. The method of separate exponentials is mathematically simple and of informational value in that it demonstrates when the early distribution phase is important. Its use can avoid the potentially dangerous assumption of one‐compartmental kinetics in the design of intravenous loading regimens. Clinical Pharmacology and Therapeutics (1981) 29, 542–547; doi: 10.1038/clpt.1981.76