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Computerized analysis of sleep recordings applied to drug evaluation: Midazolam in normal subjects
Author(s) -
Gath I,
BarOn E,
Rogowski Z,
Bental E
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.75
Subject(s) - midazolam , hypnotic , anesthesia , sleep (system call) , benzodiazepine , sleep stages , medicine , electroencephalography , audiology , psychology , polysomnography , psychiatry , sedation , computer science , receptor , operating system , apnea
Computerized analysis of poly graphic sleep recordings was carried out for the evaluation of midazolam, a benzodiazepine hypnotic. The analysis was carried out in real time on a small laboratory computer, and the output included the hypnogram and relative power profiles for the main electroencephalogram activities. Analysis showed a slight “intranight rapid eye movement rebound” during medication and reduction of sleep stage IV after withdrawal. The relative power of the delta frequency band did not change during medication or withdrawal. Clinical Pharmacology and Therapeutics (1981) 29, 533–541; doi: 10.1038/clpt.1981.75