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N ‐Acetyl‐procainamide kinetics in the elderly
Author(s) -
Galeazzi Renato L,
OmarAmberg Claudia,
Karlaganis Georg
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.61
Subject(s) - napa , procainamide , pharmacokinetics , plasma clearance , chemistry , saliva , high performance liquid chromatography , renal function , plasma concentration , body weight , half life , clearance , clinical pharmacology , pharmacology , medicine , chromatography , urology , biochemistry
Plasma and saliva N‐acetyl‐procainamide (NAPA) concentrations were measured by high‐power liquid chromatography (HPLC) after intravenous infusion of 750 mg to 14 elderly patients (x̄ age = 69 yr). The plasma NAPA disappearance curve can best be described by a two‐compartment body model. Mean total body clearance was 10.6 l/hr, Vd ss 125.8 l, and terminal half‐life (t½) 8.8 hr. A nonrenal clearance of 2.72 l/hr was calculated, that is, 19% of the expected total body clearance with normal kidney function. Saliva concentrations show huge inter‐ and intraindividual variability and are probably not usable for NAPA monitoring in older patients. Clinical Pharmacology and Therapeutics (1981) 29, 440–446; doi: 10.1038/clpt.1981.61