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Unaltered lymphocyte β‐adrenoceptor responsiveness in hyperthyroidism and hypothyroidism
Author(s) -
Smith B M,
Silas J H,
Yates Ro
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.44
Subject(s) - medicine , endocrinology , myxedema , stimulation , basal (medicine) , lymphocyte , adenosine , cyclic adenosine monophosphate , thyroid , isoprenaline , chemistry , receptor , insulin
Beta adrenoceptor sensitivity may be altered in thyrotoxicosis and myxedema. We therefore studied β‐adrenoceptor responses of peripheral blood lymphocytes to stimulation with 10 −9 to 10 −6 M(–)‐isoproterenol from patients before and after treatment of myxedema and thyrotoxicosis as well as in patients without thyroid disease. There were six patients in each group. Lymphocyte basal cyclic adenosine monophosphate (cAMP) concentrations were higher in untreated thyrotoxicosis (4.94 ± 0.46 pmole/10 6 cells) than in controls (3.47 ± 0.42 pmole/10 6 cells, p < 0.05) and in untreated myxedema (3.11 ± 0.50 pmole/10 6 cells, p < 0.025). The full isoproterenol dose‐response curves were similar in all groups. Calculated maximum velocity (Vmax) showed an approximate increase in cAMP of 14.5 pmole/10 6 cells. Isoproterenol concentrations at half‐maximum velocity (EC 30 ) were approximately 10 −8 M. It is concluded that lymphocyte β 2 ‐adrenoceptor responses are not altered in hypothyroidism and hyperthyroidism. Clinical Pharmacology and Therapeutics (1981) 29, 327–331; doi: 10.1038/clpt.1981.44