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Disopyramide hemodialysis and kinetics in patients requiring long‐term hemodialysis
Author(s) -
Sevka Michael J,
Matthews Samuel J,
Nightingale Charles H,
Izard Mark W,
Fieldman Arnold,
Chow Moses S S
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.43
Subject(s) - disopyramide , hemodialysis , dialysis , volume of distribution , medicine , urology , chemistry , pharmacology , pharmacokinetics
Disopyramide hemodialysis and kinetics after 200 mg orally in six patients receiving long‐term hemodialysis were examined. Mean volume of distribution (area) was 66.5 ± 13 1. Mean times of the peak serum concentration and mean peak serum concentration were 2.3 ± 0.9 hr and 3.1 ± 0.9 µg/ml. Mean absorption half‐life (t½) was 21.6 ± 12.5 min. Mean disopyramide elimination t½ during dialysis was 16.8 ± 11.9 hr, not significantly different from mean elimination t½ without dialysis of 16.1 ± 5.2 hr. End‐dialysis bath concentrations of disopyramide showed that not more than 2.4% of the dose was dialyzed during a 2‐hr dialysis period. Our data indicate that at therapeutic concentrations disopyramide was not appreciably dialyzed. Clinical Pharmacology and Therapeutics (1981) 29, 322–326; doi: 10.1038/clpt.1981.43