Disopyramide hemodialysis and kinetics in patients requiring long‐term hemodialysis

Disopyramide hemodialysis and kinetics after 200 mg orally in six patients receiving long‐term hemodialysis were examined. Mean volume of distribution (area) was 66.5 ± 13 1. Mean times of the peak serum concentration and mean peak serum concentration were 2.3 ± 0.9 hr and 3.1 ± 0.9 µg/ml. Mean absorption half‐life (t½) was 21.6 ± 12.5 min. Mean disopyramide elimination t½ during dialysis was 16.8 ± 11.9 hr, not significantly different from mean elimination t½ without dialysis of 16.1 ± 5.2 hr. End‐dialysis bath concentrations of disopyramide showed that not more than 2.4% of the dose was dialyzed during a 2‐hr dialysis period. Our data indicate that at therapeutic concentrations disopyramide was not appreciably dialyzed. Clinical Pharmacology and Therapeutics (1981) 29, 322–326; doi: 10.1038/clpt.1981.43