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Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects
Author(s) -
Mitch William E,
Johnson Michael W,
Kirshenbaum James M,
Lopez Robert E
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.42
Subject(s) - uric acid , ascorbic acid , excretion , urine , chemistry , medicine , endocrinology , renal physiology , kidney , food science
The effects of large oral doses of ascorbic acid on renal clearance and excretion of uric acid were studied in nongouty subjects because ascorbic acid has been reported to increase renal uric acid clearance. Our results indicate that 4 or 12 gm ascorbic acid taken in divided doses had no effect on serum uric acid concentration or uric acid excretion and clearance by the kidney. Reasons for these results, which differ from previous reports, are discussed. We quantitated the magnitude of the interference of ascorbic acid in the measurement of uric acid by the nonspecific methods frequently used, since falsely elevated urine uric acid could lead to misinterpretation of screening tests. Clinical Pharmacology and Therapeutics (1981) 29, 318–321; doi: 10.1038/clpt.1981.42