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Renal hemodynamic changes during long‐term antihypertensive therapy
Author(s) -
Warren Sanford E,
O'Connor Daniel T,
Cohen Irving M,
Mitas John A
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.41
Subject(s) - hydrochlorothiazide , medicine , guanabenz , furosemide , hemodynamics , clonidine , prazosin , diuretic , blood pressure , clinical pharmacology , essential hypertension , propranolol , pharmacology , cardiology , antagonist , receptor , agonist
Studies of renal hemodynamics were carried out in 84 patients with essential hypertension during long‐term antihypertensive therapy with a number of drugs. Renal perfusion was maintained or enhanced despite a fall in mean arterial pressure during therapy with hydrochlorothiazide, furosemide, clonidine, prazosin, and the combination of guanabenz and hydrochlorothiazide. Renal perfusion deteriorated during long‐term treatment with propranolol. Renal hemodynamics may be enhanced, maintained, or adversely influenced depending on the choice of antihypertensive agent. Clinical Pharmacology and Therapeutics (1981) 29, 310–317; doi: 10.1038/clpt.1981.41