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Exercise duration to angina at two and twelve hours after timolol
Author(s) -
Aronow Wilbert S,
Plasencia Gilbert,
Wong Raymond,
Landa Daniel
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.25
Subject(s) - timolol , placebo , angina , medicine , crossover study , anesthesia , drug , duration (music) , pharmacology , surgery , myocardial infarction , intraocular pressure , art , alternative medicine , literature , pathology
Eight patients who improved their exercise duration to angina or marked fatigue (≥25%) on timolol 10 to 30 mg twice daily over that on placebo 8 to 14 mo previously were subjects in a double‐blind, randomized, crossover 4‐wk study of the effect of timolol on exercise duration 2 and 12 hr after medication. One patient was discontinued from the study because unstable angina developed on placebo. Mean exercise duration on timolol over control was increased at 12 hr (p < 0.02) and at 2 hr (p < 0.001) after drug. There was an increase in exercise duration ≥25% on timolol over control compared with placebo in three of seven patients (43%) 12 hr after drug and in seven of seven (100%) 2 hr after drug. Timolol 10 to 30 mg twice daily prolongs exercise duration to angina or marked fatigue at 2 hr after drug and in some responders at 12 hr after drug. Clinical Pharmacology and Therapeutics (1981) 29, 155–159; doi: 10.1038/clpt.1981.25