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Food‐induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites
Author(s) -
Walle Thomas,
Fagan Timothy C,
Walle U Kristina,
Oexmann MaryJoan,
Conradi Edward C,
Gaffney Thomas E
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.239
Subject(s) - bioavailability , propranolol , meal , chemistry , pharmacology , pharmacokinetics , urine , clinical pharmacology , drug , metabolism , oral administration , food science , endocrinology , medicine , biochemistry
The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range, 2% to 92%; P < 0.01) without affecting time to maximum concentration, half‐life, or the amount of unchanged drug in urine. There was no effect on the plasma concentrations of 4‐hydroxypropranolol or four other metabolites. The increased bioavailability was linearly related to the protein content of the meal (r = 0.884, P < 0.02) above a threshold content of about 7 gm. Clinical Pharmacology and Therapeutics (1981) 30 , 790–795; doi: 10.1038/clpt.1981.239