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Determinants of response to intravenous hydralazine in hypertension
Author(s) -
Shepherd Alexander,
Lin MinShung,
McNay John,
Ludden Thomas,
Musgrave Gary
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.237
Subject(s) - hydralazine , medicine , dosing , blood pressure , pharmacology , intravenous infusions , clinical pharmacology , pharmacokinetics , systemic circulation , drug response , drug , anesthesia
There is marked interindividual variation in hypotensive response to intravenous hydralazine (H). We examined the determinants of response in patients with hypertension. After a single intravenous dose of 0.3 mglkg H, response was correlated independently (r = 0.8364) with both predrug blood pressure and acetylator index (AI). Intravenous dose ranging studies showed that response also depended on the amount of H in the systemic circulation. Although plasma H levels depend on AI after oral doses, this is not so after intravenous administration. AI must therefore affect response to H by an alternative, presumably nonmetabolic mechanism which, after oral dosing, would add to its effect on H levels. Response to intravenous nitroprusside was not related to AI, perhaps indicating specificity of this effect for H. These data reinforce the potential usefulness of determining Al before giving H to a patient. Clinical Pharmacology and Therapeutics (1981) 30 , 773–781; doi: 10.1038/clpt.1981.237