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Plasma clonidine concentration and pharmacologic effect
Author(s) -
Hogan Michael J,
Wallin John D,
Chu LiChiang
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.230
Subject(s) - clonidine , blood pressure , plasma concentration , clinical pharmacology , anesthesia , plasma levels , medicine , pharmacology , diastole , chemistry , endocrinology
Analysis of sequential plasma samples in 14 hypertensive subjects receiving their usual oral dose of clonidine (0.1 to 0.6 mg twice daily) indicated that clonidine plasma concentration increased for the first 2 hr and then decreased and stabilized over the next 12 hr. Percent fall in diastolic blood pressure, but not side effects, correlated well with plasma concentration. Our study indicates a potential role for plasma clonidine determination in the treatment of patients with hypertension. It also demonstrates that clonidine can probably be given at 12‐hr intervals and be effective. Clinical Pharmacology and Therapeutics (1981) 30 , 729–734; doi: 10.1038/clpt.1981.230