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Kinetics and renal handling of cefonicid
Author(s) -
Pitkin Donald,
Dubb Jeffrey,
Actor Paul,
Alexander Fred,
Ehrlich Stephen,
Familiar Robert,
Stote Robert
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.208
Subject(s) - probenecid , intramuscular injection , pharmacology , renal physiology , pharmacokinetics , renal function , medicine , chemistry
Cefonicid kinetics were determined after intravenous and intramuscular injection and the renal handling of the drug was examined, including the effect of probenecid on its excretion. Peak serum levels after 1000 and 500 mg intravenously were 221 and 91 μg/ml. The half‐life (t½) was the same for both regimens (3.5 hr). Intramuscular injection of the 1000‐ and 500‐mg doses resulted in peak serum levels of 112 and 40 μg/ml. When probenecid was given with the 500‐mg dose, the peak serum level was 61 μg/ml and the time to peak level rose from 13 to 2.5 hr. The t½ after 1000 and 500 mg alone was much the same at 4.8 and 4.9 hr. The addition of probenecid to the 500‐mg dose extended the t½ to 7.5 hr. Renal clearance, excretion, and secretion rates for cefonicid were reduced by the addition of probenecid. Cefonicid's long t½ and high blood levels max provide clinical efficacy with a single daily dose. Clinical Pharmacology and Therapeutics (1981) 30, 587–593; doi: 10.1038/clpt.1981.208