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Onset of peak impairment after diazepam and after alcohol
Author(s) -
Ellinwood Everett H,
Linnoila Markku,
Easler Martha E,
Molter David W
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.199
Subject(s) - diazepam , psychomotor learning , cognitive impairment , medicine , anesthesia , ingestion , alcohol , blood alcohol , memory impairment , psychology , cognition , poison control , psychiatry , injury prevention , emergency medicine , chemistry , biochemistry
Single doses of diazepam induced peak impairment of performance on cognitive and psychomotor tasks early (20 min after ingestion), when blood levels had reached less than two thirds of their eventual plateau. Alcohol did not have this effect. Early peak impairment and the acute tolerance that follows it contribute greatly to the lack of correlation between diazepam plasma level and performance impairment. Clinical Pharmacology and Therapeutics (1981) 30, 534–538; doi: 10.1038/clpt.1981.199