Moxalactam kinetics in hemodiaiysis

In eight patients with end‐stage renal disease undergoing chronic hemodiaiysis moxalactam kinetics were examined. Volume of distribution (V d ), dialysance (C d ), and serum half‐life (t½) were determined during dialysis with a 1.3 or 1.6 m 2 dialyzer. The t½ was also determined during the interdialytic period. V d was 0.25 ± 0.04 l/kg and C d was 32.6 ± 11.7 ml/min and 67 ± 25.5 ml/min with the 1.3 and 1.6 m 2 dialyzers. The t½ was 4.8 ± 0.9 hr using the 1.3 m 2 dialyzer and 2.8 ± 0.6 hr using the 1.6 m 2 dialyzer. Moxalactam t½ during the interdialytic period was 23.4 ± 9.6 hr. Clinical Pharmacology and Therapeutics (1981) 30, 487–490; doi: 10.1038/clpt.1981.192