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Ceforanide kinetics in renal insufficiency
Author(s) -
Hawkins Stephen S,
Alford Robert H,
Stone William J,
Smyth Robert D,
Pfeffer Morris
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.190
Subject(s) - hemodialysis , medicine , dialysis , renal function , urology , plasma clearance , metabolic clearance rate , dosing , clearance , chronic renal insufficiency , pharmacokinetics , creatinine
Ceforanide (500 mg) was infused intravenously over 30 min into six normal subjects, 10 nondialysis patients with renal insufficiency, and six hemodialysis patients. Dialysis patients received two ceforanide infusions, one immediately before dialysis and another during an interdialysis period. Sequential plasma samples over 24 to 72 hr were assayed for ceforanide. Peak ceforanide levels (mean = 69 ± 12 μg/ml) and volumes of distribution did not vary with creatinine clearance (Cl cr , ml/min/1.73 m 2 ) and both plasma clearance and renal clearance decreased linearly as Cl cr decreased. Mean nonrenal clearance (4.6 ± 1.8 ml/min/1.73 m 2 ) did not vary with Cl cr . Mean half‐life was 3 hr in the normal subjects, increasing to approximately 25 hr in patients with severe renal insufficiency. Hemodialysis resulted in removal of approximately 21% of the dose of ceforanide. Dosing recommendations for patients with renal insufficiency are provided. Clinical Pharmacology and Therapeutics (1981) 30, 468–474; doi: 10.1038/clpt.1981.190