Effects of caffeine withdrawal on isoproterenol‐stimuiated cyclic adenosine monophosphate | Zendy

Mackenzie Thomas B | Zendy; Popkin Michael K | Zendy; Dziubinski Joseph | Zendy; Sheppard John R | Zendy

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Effects of caffeine withdrawal on isoproterenol‐stimuiated cyclic adenosine monophosphate

Author(s) -

Mackenzie Thomas B,

Popkin Michael K,

Dziubinski Joseph,

Sheppard John R

Publication year - 1981

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.1981.185

Subject(s) - caffeine , endocrinology , adenosine , medicine , prostaglandin e1 , chemistry , theophylline , cyclic adenosine monophosphate , pharmacology , receptor

The effect of short‐term caffeine withdrawal on lymphocyte beta‐adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E 1 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine‐withdrawal syndrome Clinical Pharmacology and Therapeutics (1981) 30, 436–438; doi: 10.1038/clpt.1981.185

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