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Prediction of creatinine clearance from serum creatinine concentration based on lean body mass
Author(s) -
Hallynck Thierry,
Soep Hans H,
Thomis Jozef,
Boelaert Johann,
Daneels Roger,
Fillastre Jean P,
De Rosa Franco,
Rubinstein Ethan,
Hatala Milan,
Spousta Josef,
Dettli Lucius
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.181
Subject(s) - renal function , creatinine , aminoglycoside , urology , clinical pharmacology , lean body mass , endocrinology , chemistry , medicine , antibiotics , pharmacology , body weight , biochemistry
An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentrations is presented. The predictions are compared with four other available estimating methods, based on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the correlation between measured and predicted CrCl was better with the new equation. In patients with rapidly changing renal function the new equation resulted in accurate predictions of CrCl within a few hours after the change, as opposed to several days with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation than with those measured during 24 hr or with the other prediction methods. Clinical Pharmacology and Therapeutics (1981) 30 , 414–421; doi: 10.1038/clpt.1981.181