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Penicillamine kinetics in normal subjects
Author(s) -
Bergstrom Richard F,
Kay Donald R,
Harkcom Thomas M,
Wagner John G
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.180
Subject(s) - penicillamine , plasma clearance , chemistry , endocrinology , plasma levels , medicine , kinetics , half life , pharmacokinetics , pharmacology , physics , quantum mechanics
The kinetic characteristics of penicillamine are reported in four fasting subjects after four oral doses each. On later test days, two of the subjects received an additional single dose 30 min after a large breakfast. One subject originally included in the study had to drop out because of gastrointestinal disturbances following each of two single doses of penicillamine. The fasting plasma levels of penicillamine observed in this study displayed an unusual double peak in the plasma levels after single doses. Individual subjects had consistent plasma level patterns for each of the four single doses but there was marked intersubject variability in patterns and kinetic parameters. The half‐life of unchanged penicillamine ranged from 1.66 to 3.15 hr and the apparent plasma clearance ranged from 530 to 2300 ml/min. The administration of penicillamine following a large breakfast caused a reduction in the area under the penicillamine plasma concentration‐time curve corresponding to a decrease in the extent of absorption of unchanged penicillamine. Clinical Pharmacology and Therapeutics (1981) 30 , 404–413; doi: 10.1038/clpt.1981.180