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Lack of difference in digoxin urinary excretion with two intravenous infusion rates
Author(s) -
Lindenbaum John,
Long Robert,
Wenger Thomas,
Mallis George,
Cato Allen
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.166
Subject(s) - digoxin , intravenous bolus , radioimmunoassay , excretion , urine , bolus (digestion) , urinary system , medicine , endocrinology , chemistry , pharmacology , anesthesia , heart failure
Ten normal subjects were given 0.4 mg digoxin intravenously by bolus injection over 3 to 5 min and by constant‐rate infusion for 1 hr. Urinary excretion of digoxin over the next 6 days, as measured by radioimmunoassay, was similar after both the rates of intravenous injection. In one subject, who excreted substantial amounts of digoxin reduction products, no difference was apparent in the amount of reduced metabolites excreted. These results are not in agreement with previous reports of an effect of intravenous infusion rate on urinary digoxin excretion. Clinical Pharmacology and Therapeutics (1981) 30 , 317–320; doi: 10.1038/clpt.1981.166