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Propranolol and sotalol as antagonists of isoproterenol‐enhanced physiologic tremor
Author(s) -
Pickles Hilary,
Perucca Emilio,
Fish Alison,
Richens Alan
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.164
Subject(s) - sotalol , propranolol , heart rate , antagonist , antiarrhythmic agent , medicine , anesthesia , bolus (digestion) , pharmacology , cardiology , heart disease , atrial fibrillation , blood pressure , receptor
Six normal subjects were studied after graded bolus injections of isoproterenol. Log dose‐response curves for increases in both heart rate (mostly β 1 ) and amplitude of physiologic tremor (β 2 ) were constructed for each subject in the control state and 2 hr after 10 or 40 mg propranolol, 200 mg sotalol, or placebo. All heart rate curves were shifted to the right in an approximately parallel fashion by all active treatments (40 mg propranolol > 200 mg sotalol > 10 mg propranolol). The tremor curve was also shifted to the right by 10 mg propranolol in an approximately parallel fashion and to the same extent as the heart rate curve (both dose‐ratios = 6.1), but the tremor curves after both 40 mg propranolol and 200 mg sotalol appeared to be flattened as well as shifted laterally. We conclude that whereas it may be possible that 10 mg propranolol acts as a competitive antagonist of isoproterenol at β 2 ‐sites in skeletal muscle, 40 mg propranolol and 200 mg sotalol must have additional actions in reducing isoproterenol tremor. The possibilities are discussed. Clinical Pharmacology and Therapeutics (1981) 30 , 303–310; doi: 10.1038/clpt.1981.164