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Assessment of beta blockade with propranolol
Author(s) -
Hager W David,
Pieniaszek Henry J,
Perrier Donald,
Mayersohn Michael,
Goldberger Virginia
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.161
Subject(s) - propranolol , heart rate , blockade , placebo , medicine , tachycardia , beta (programming language) , anesthesia , cardiology , blood pressure , receptor , alternative medicine , pathology , computer science , programming language
Each of seven subjects received on a weekly basis placebo or 10, 20, 40, 80, or 160 mg propranolol orally four times daily. The effect of propranolol on the resting heart rate and the heart rate response to the Valsalva maneuver, tilt, isoproterenol, and maximal exercise were measured. Coefficients of determination were calculated from the individual dose‐response curves. The results indicate that the resting heart rate and the tachycardiac response to the Valsalva maneuver and tilt cannot be used to estimate beta blockade. Propranolol concentrations correlated well (mean r 2 = 0.80) with the isoproterenol dose ratio minus one, but isoproterenol challenges appear clinically inapplicable. Reduction in maximal exercise tachycardia correlated best with propranolol concentrations (mean r 2 = 0.89) but, to the extent that exercise could not be performed, there was no reliable way of clinically documenting beta blockade and only the serum concentration of propranolol was available as an indicator of appropriate therapy. Clinical Pharmacology and Therapeutics (1981) 30 , 283–290; doi: 10.1038/clpt.1981.161