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Clodronate kinetics and dynamics
Author(s) -
Conrad Kenneth A,
Lee Stanley M
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.135
Subject(s) - chemistry , excretion , renal function , creatinine , fractional excretion of sodium , urine , endocrinology , uric acid , medicine , pharmacology , biochemistry
Clodronaie disodium (C1 2 MDP) was given intravenously in doses of 3, 6, and 10 mg/kg to six men (aged 23 to 30 yr). Volume of distribution was 0.2720 ± 0.0255 l/kg (x̄ ± SD) after 3 mg/kg dose, 0.3037 ± 0.0445 l/kg after 6 mg/kg, and 0.2528 ± 0.0417 l/kg after 10 mg/kg. The elimination rate constant was 0.3787 ± 0.0546 hr −1 , 0.3492 ± 0.0616 hr −1 , and 0.3962 ± 0.0358 hr −1 after 3, 6, and 10 mg/kg. Corresponding total body clearances were 0.1026 ± 0.0149, 0.1049 ± 0.0159, and 0.0998 ± 0.0172 1/kg/hr. Renal clearance accounted for 73% of total body clearance; 73% of the drug was excreted unchanged in the urine in 24 hr. After Cl 2 MDP serum phosphate decreased approximately 13%; this was associated at the 10 mg/kg dose with a transient fall in fractional phosphate excretion. There were no significant changes in the serum concentration or fractional excretion of calcium, sodium, or uric acid. Creatinine clearance and renal concentrating ability were not altered by Cl 2 MDP. After short‐term administration Cl 2 MDP is excreted primarily by the kidney but has no significant effects on renal function. Clinical Pharmacology and Therapeutics (1981) 30, 114–120; doi: 10.1038/clpt.1981.135