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Effects of diuretic and propranolol on plasma lipoprotein lipids
Author(s) -
Bauer John H,
Brooks Charles S,
Weinstein Ira,
Wilcox Henry H,
Heimberg Murray,
Burch Rebecca N,
Barkley Rachael
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.124
Subject(s) - diuretic , hydrochlorothiazide , very low density lipoprotein , propranolol , chemistry , triglyceride , endocrinology , lipoprotein , medicine , cholesterol , phospholipid , pharmacology , biochemistry , membrane , blood pressure
Ticrynafen (TCNF), a nonthiazide diuretic, has been reported to be nonhyperlipidemic. To define the effects of these drugs on plasma lipoproteins, experiments were performed in hypertensive subjects after placebo therapy, 4 wk after therapy with either hydrochlorothiazide (HCTZ) or TCNF, 3 mo after diuretic with propranolol, and 1 mo after therapy with propranolol alone. Plasma lipoproteins were separated by ultracentrifugation and the lipid fractions isolated by extraction and silicic acid thin‐layer chromatography. Plasma low‐density lipoprotein (LDL) total cholesterol fell and high‐density lipoprotein (HDL) total cholesterol rose in subjects receiving TCNF. TCNF had no effect on plasma very low‐density lipoprotein (VLDL) triglyceride or phospholipid. There were no significant changes in LDL or HDL total cholesterol in subjects on HCTZ. HCTZ tended to increase plasma VLDL triglyceride and phospholipid. The addition of propranolol to either diuretic had no effect on LDL or HDL total cholesterol but increased VLDL triglyceride, especially in subjects on HCTZ. Propranolol alone had no effect on any of the lipids measured. Clinical Pharmacology and Therapeutics (1981) 30, 35–43; doi: 10.1038/clpt.1981.124