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Variations in glycerol kinetics in Reye's syndrome
Author(s) -
Nahata Milap C,
Kerzner Benny,
McClung H Juling,
Sherard Earl S,
Hilty Milo D
Publication year - 1981
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1981.111
Subject(s) - glycerol , transaminase , chemistry , blood urea nitrogen , reye's syndrome , urea , medicine , hemolysis , endocrinology , creatinine , biochemistry , enzyme
Glycerol kinetics and adverse effects were studied in nine patients with Reye's syndrome. Glycerol was given by continuous infusion over 2 hr, half over the first 0.5 hr and the remainder over the next 1.5 hr. The dose was adjusted to keep intracranial pressure ≤15 mmHg. At steady state, serial blood samples were collected during glycerol infusion and analyzed by an enzymatic assay specific for glycerol. At 0.75 to 1.75 gm/kg/2 hr glycerol doses, the serum levels ranged from 1.48 to 5.83 mg/ml. Total body clearance ranged from 1.99 to 5.1 ml/kg/min. Glycerol clearance was not related to serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), or serum ammonia levels. Glycerol provided effective control of intracranial pressure in all patients. Temporary elevation of serum creatinine and blood urea nitrogen (BUN) and presence of hemolysis in two patients appeared to be related to glycerol. Clinical Pharmacology and Therapeutics (1981) 29 , 782–787; doi: 10.1038/clpt.1981.111